New PDF release: Adipocytokines, Energy Balance, and Cancer

By Ofer Reizes, Nathan A. Berger

ISBN-10: 3319416758

ISBN-13: 9783319416755

ISBN-10: 3319416774

ISBN-13: 9783319416779

Adipocytokines give you the circuitry during which adipose tissue communicates between its part cells which come with adipocytes, stromal cells, immune cells and vascular components, with adipose tissue depots in different destinations in the course of the physique and with different tissues that allows you to keep an eye on physiologic strategies of strength consumption, usage, and distribution. in view that disturbances, either qualitative and quantitative, in adipocytokine functionality give a contribution considerably to the various comorbidities linked to weight problems, together with diabetes, heart problems and melanoma, this quantity, which discusses many of the significant adipocytokines independently and jointly and their roles in general and pathologic techniques, might be beneficial to all participants looking a deeper realizing of those tactics. additionally, it offers a important supplement to the sequence on Energy stability and Cancer, during which every one quantity is targeted on a selected point of this procedure, which now constitutes an increasing challenge because the weight problems pandemic keeps and extra of the inhabitants reaches the age the place melanoma is so much wide-spread. This quantity should still offer a necessary source to all clinicians and scientists engaged in taking good care of vulnerable sufferers and in exploring the relation among power stability and melanoma in addition to a major platform to supplying the history for learn development.

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Extra resources for Adipocytokines, Energy Balance, and Cancer

Example text

Cytogenet Genome Res 112:148–151 18. Shapiro L, Scherer PE (1998) The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr Biol 8:335–338 19. Obeid S, Hebbard L (2012) Role of adiponectin and its receptors in cancer. B. P. Kirwan 20. Tsao TS, Tomas E, Murrey HE, Hug C, Lee DH, Ruderman NB, Heuser JE, Lodish HF (2003) Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways.

Vojnosanit Pregl 70:284–291 Chapter 3 Leptin in Cancer: Epidemiology and Mechanisms Margot P. Cleary and Marta Torroella-Kouri Abstract Obesity is now considered a risk factor for many cancers. In particular, the risk of developing postmenopausal breast cancer is elevated in overweight/ obese women. Leptin, an adipokine made in adipose tissue, may be a physiological link between cancer and obesity. Epidemiological studies in some cases report elevated leptin levels in women with breast cancer and expression of the leptin receptor (Ob-R) in breast tumors.

It can operate also at distant levels, through secretion from adipocytes into the circulation to modulate insulin sensitivity at the target tissue site, regulating inflammatory responses, and influencing tumor angiogenesis. Numerous cellular signaling pathways are affected by the presence of adiponectin. The majority of adiponectin signaling in cancer is exerted via the important cellular metabolic rate control point—5′ adenosine monophosphate-activated protein kinase (AMPK). Adiponectin directly controls cell proliferation, adhesion, invasion, and colony formation by regulating AMPK to promote growth arrest and apoptosis via increased p53 and p21 expressions, respectively [52, 53].

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Adipocytokines, Energy Balance, and Cancer by Ofer Reizes, Nathan A. Berger


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