Cancer and Development by Michael A. Dyer (Eds.) PDF

By Michael A. Dyer (Eds.)

ISBN-10: 0123809169

ISBN-13: 9780123809162

In recent times, a couple of molecular pathways and mobile methods which are crucial for regular vertebrate improvement were implicated in melanoma initiation and development. during this quantity, leaders within the box of melanoma genetics and developmental biology proportion fresh insights into the significance of developmental pathways for tumorigenesis. those discoveries offer very important avenues for cutting edge new ways to treating the most demanding developmental tumors.Provides researchers an summary and synthesis of the most recent examine findings and modern concept within the areaThere at the moment are a number of molecular specified remedies for the remedy of melanoma. lots of those treatments aim pathways which are crucial for regular improvement. accordingly, this quantity offers an up-to-the-minute and well timed viewpoint on these pathways and organic techniques that carry the best promise for specified intervention. 

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It was demonstrated that as few as 100 CD133þ tumor cells were sufficient to give rise to glioblastoma in immunodeficient mice, whereas the CD133À population was not as tumorigenic. , 2009), have been used to identify these cells. Glioma stem cells, similar to NSCs, can be cultured as suspended spheres in serum-free environment with growth factors, and differentiate during growth factor withdrawal. At the present, however, there seems to be no consensus on a universal marker for cancer stem cells in gliomas.

Cancer 6, 184–192. , and Ruiz i Altaba, A. (2001). The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development 128, 5201–5212. , Cho, R. , and Clarke, M. F. (2007). Cancer stem cells: models and concepts. Annu. Rev. Med. 58, 267–284. , White, D. , Bennett, B. , Bittinger, M. , Driggers, E. , Fantin, V. , Jang, H. , Keenan, M. , Marks, K. , Prins, R. , et al. (2009). Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462, 739–744. , Lee, J. , Yang, G.

Biol. 17, 165–172. Corsten, M. , Krichevsky, A. , and Shah, K. (2007). MicroRNA-21 knockdown disrupts glioma growth in vivo and displays 38 Sheila R. Alcantara Llaguno et al. synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. Cancer Res. 67, 8994–9000. , Levine, A. , and Mak, T. W. (2006). Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat. Rev. Cancer 6, 184–192. , and Ruiz i Altaba, A. (2001). The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis.

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Cancer and Development by Michael A. Dyer (Eds.)


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