By Rajendra Prasad
This publication on Candida albicans and related pathogens presents a well timed evaluate of the groundbreaking discoveries made within the components of drug resistance, host–pathogen interactions, virulence, host immune approach modulation, etc., within the final decades.
This finished second version contains chapters on fungal infections, hyphal morphogenesis, molecular mechanisms of antifungal resistance, antifungal brokers, multidrug transporters, virulence mechanisms in Candida albicans, host–pathogen interactions, the mobilephone wall, fungal biofilms, lipids and antifungal resistance, signaling mechanisms and final yet now not the least host-immune responses. As such, it bargains a terrific reference consultant for mycologists, researchers, pharmacists, clinicians, and undergraduate scholars engaged or drawn to fungal examine. it is going to additionally profit clinicians, who're required to maintain abreast of the present kingdom of study on antifungal drug resistance and antifungal development.
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Extra info for Candida albicans: Cellular and Molecular Biology
The use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis: recommendations from the Third European Conference on Infections in Leukemia. Crit Care 14:R222 Montravers P, Dupont H, Gauzit R, Veber B, Auboyer C, Blin P, Hennequin C, Martin C (2006) Candida as a risk factor for mortality in peritonitis. Crit Care Med 34:646–652 Montravers P, Leroy O, Eckmann C (2015) Intra-abdominal candidiasis: it’s still a long way to get unquestionable data. Intensive Care Med 41:1682–1684 Morrell M, Fraser VJ, Kollef MH (2005) Delaying the empiric treatment of Candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality.
Invasive candidiasis is often endogenous in origin, unlike most of the other mycoses. Candidiasis ranges from superﬁcial infection, encompassing the skin and mucous membrane, to invasive disease, involving the bloodstream and/or other body organs either through secondary dissemination or direct inoculation of the fungus at sterile body sites. The major clinical manifestations of invasive candidiasis include candidemia, abdominal candidiasis, endocarditis, endophthalmitis, meningitis, urinary tract infection, osteomyelitis, hepatosplenic candidiasis and other disseminated forms (Kullberg and Arendrup 2015; Pappas et al.
Surrogate markers such as b-D-glucan, mannan and anti-mannan antibodies have also been employed for serological diagnosis of invasive candidiasis. The speciﬁcity and diagnostic accuracy of b-D-glucan assay is higher than Candida score and colonization index (Posteraro et al. 2011; Pappas et al. 2016). It particularly has a high negative predictive value, and is useful in identifying ICU patients at higher risk of IFIs as well as for monitoring the response to treatment (Jaijakul et al. 2012; Chen 2013; Kullberg and Arendrup, 2015).
Candida albicans: Cellular and Molecular Biology by Rajendra Prasad