By Rebecca A. Bader
Polymers have performed a severe position within the rational layout and alertness of drug supply platforms that raise the efficacy and decrease the toxicity of latest and standard therapeutics. starting with an creation to the basics of drug supply, Engineering Polymer platforms for enhanced Drug Delivery explores conventional drug supply suggestions in addition to rising complicated drug supply ideas. via reviewing many varieties of polymeric drug supply structures, and together with key issues, labored examples and homework difficulties, this ebook will function a advisor to for experts and non-specialists in addition to a graduate point textual content for drug supply courses.
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Additional info for Engineering Polymer Systems for Improved Drug Delivery
One Dimensional Flux Equations for Different Geometries ∂c ∂ 2 c1 = 1 2 ∂t dz Rectangular D1 Cylindrical D1 1 ∂c1 ∂ 2 c1 + r ∂r dr 2 Spherical D1 ∂c 2 ∂c ∂ 2 c1 = 1 + r ∂r ∂t dr 2 = ∂c1 ∂t Although Fick’s Second Law was derived for one dimension ﬂux in a rectangular coordinate system above, these concepts can readily be extended to spherical and cylindrical coordinate systems (Fig. 7). 3. 1, can be found in Crank’s book on the mathematics of diffusion . 1 Application of Fick’s Second Law in Drug Delivery.
Zaffaroni A. Systems for controlled drug delivery. Med Res Rev 1981;1(4):373–386. 24. Gillies ER, Frechet JM. Dendrimers and dendritic polymers in drug delivery. Drug Discov Today 2005;10(1):35–43. 25. Lee CC et al. A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas. Proc Natl Acad Sci U S A 2006;103(45):16649–16654. 26. Padilla De Jesus OL et al. Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation. Bioconjug Chem 2002;13(3):453–461.
34 CHALLENGES OF DRUG DELIVERY surface, that seal off the pathway between cells, thereby preventing harmful substances and therapeutic molecules from traveling through the membrane . Tight junctions are composed of transmembrane proteins with adhesive properties, including occludins, claudins, and the recently discovered tricellulin . Adherens junctions are typically located below the tight junctions. The primary components of these cells are cadherins, which are adhering proteins requiring the presence of calcium to maintain adhesiveness.
Engineering Polymer Systems for Improved Drug Delivery by Rebecca A. Bader