Frontiers in Cancer Research: Evolutionary Foundations, by Carlo C. Maley, Mel Greaves PDF

By Carlo C. Maley, Mel Greaves

ISBN-10: 1493964585

ISBN-13: 9781493964581

ISBN-10: 1493964607

ISBN-13: 9781493964604

This is the right booklet for an individual considering beginning a occupation in, or transferring their occupation to, learning the dynamics that force melanoma development and its reaction to treatment. issues comprise the speculation and inhabitants genetics of cancers, genetic variety inside tumors (intra-tumor heterogeneity), figuring out how mutant clones extend in tissues, the position of melanoma stem cells within the dynamics of tumors, the evolution of metastasis, and the way to enhance melanoma remedy by way of addressing the evolution of cancers based on our interventions. There also are chapters at the styles of melanoma susceptibility in people as a result of a mismatch among our glossy atmosphere and the surroundings during which our ancestors developed, in addition to a bankruptcy at the evolution of melanoma suppression mechanisms that experience developed in numerous species, rather the big long-lived animals like elephants and whales which are greater at suppressing cancers than people.

This e-book serves as a primer at the evolutionary and ecological conception of melanoma- the framework upon which all of the information of melanoma might be hung. it truly is perfect for oncologists and melanoma researchers drawn to evolutionary idea, and evolutionary biologists and ecologists attracted to gaining insights into melanoma improvement and prevention.

Show description

Read or Download Frontiers in Cancer Research: Evolutionary Foundations, Revolutionary Directions PDF

Similar forensic medicine books

Get Essential Forensic Pathology: Core Studies and Exercises PDF

A myriad of alternative eventualities watch for these coming into the sphere of forensic pathology, starting from gunshot wounds to asphyxiation to explosives to demise from dependancy. crucial Forensic Pathology: middle reports and workouts is helping arrange pathologists in education via constructing what they need to find out about the commonest dying scenes they'll come upon.

Read e-book online Psychology and Law: The State of the Discipline PDF

As legislations is instituted by way of society to serve society, there might be absolute confidence that psychology performs a major and inevitable position within the felony procedure, clarifying or complicating criminal matters. during this enlightening textual content, Roesch, Hart, Ogloff, and the individuals evaluation all of the key parts of using mental services in civil, felony, and relations legislation.

Unimagined Community: Sex, Networks, and AIDS in Uganda and by Robert Thornton PDF

This groundbreaking paintings, with its distinctive anthropological process, sheds new gentle on a valuable conundrum surrounding AIDS in Africa. Robert J. Thornton explores why HIV incidence fell through the Nineties in Uganda regardless of that country's having one in all Africa's optimum fertility premiums, whereas in the course of the related interval HIV incidence rose in South Africa, the rustic with Africa's lowest fertility expense.

Additional info for Frontiers in Cancer Research: Evolutionary Foundations, Revolutionary Directions

Example text

Merlo LMF, Pepper JW et al (2006) Cancer as an evolutionary and ecological process. Nat Rev Cancer 6(12):924–935 9. Greaves M, Maley CC (2012) Clonal evolution in cancer. Nature 481(7381):306–313 10. Podlaha O, Riester M et al (2012) Evolution of the cancer genome. Trends Genet 28(4):155–163 11. Horne SD, Pollick SA et al (2015) Evolutionary mechanism unifies the hallmarks of cancer. Int J Cancer 136:2012–2021 12. Aktipis CA, Maley CC, Neuberg SL (2010) Psychological barriers to evolutionary thinking in medicine.

Springer, New York, pp 1–13 79. Boerkamp K, Rutteman G et al (2012) Nuclear DNA-content in mesenchymal lesions in dogs: its value as marker of malignancy and extent of genomic instability. Cancers (Basel) 4(4):1300–1317 80. Liu YR, Kirkland B et al (2013) Development of a single-cell array for large-scale DNA fluorescence in situ hybridization. Lab Chip 13(7):1316–1324 81. Basu S, Zaidi H et al (2007) Novel quantitative techniques for assessing regional and global function and structure based on modern imaging modalities: implications for normal variation, aging and diseased states.

Bioessays 33(5):332–340 38. Shah SP, Roth A et al (2012) The clonal and mutational evolution spectrum of primary triplenegative breast cancers. Nature 486(7403):395–399 39. Shah SP, Morin RD et al (2009) Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature 461(7265):809–813 2 The Role of Theory in Cancer Research 29 40. Navin N, Kendall J et al (2011) Tumour evolution inferred by single-cell sequencing. Nature 472(7341):90–94 41. Ng CKY, Cooke SL et al (2012) The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer.

Download PDF sample

Frontiers in Cancer Research: Evolutionary Foundations, Revolutionary Directions by Carlo C. Maley, Mel Greaves


by Christopher
4.2

Rated 4.67 of 5 – based on 49 votes