Frontiers in Cancer Research: Evolutionary Foundations, by Carlo C. Maley, Mel Greaves PDF

By Carlo C. Maley, Mel Greaves

ISBN-10: 1493964585

ISBN-13: 9781493964581

ISBN-10: 1493964607

ISBN-13: 9781493964604

This is the right booklet for an individual considering beginning a occupation in, or transferring their occupation to, learning the dynamics that force melanoma development and its reaction to treatment. issues comprise the speculation and inhabitants genetics of cancers, genetic variety inside tumors (intra-tumor heterogeneity), figuring out how mutant clones extend in tissues, the position of melanoma stem cells within the dynamics of tumors, the evolution of metastasis, and the way to enhance melanoma remedy by way of addressing the evolution of cancers based on our interventions. There also are chapters at the styles of melanoma susceptibility in people as a result of a mismatch among our glossy atmosphere and the surroundings during which our ancestors developed, in addition to a bankruptcy at the evolution of melanoma suppression mechanisms that experience developed in numerous species, rather the big long-lived animals like elephants and whales which are greater at suppressing cancers than people.

This e-book serves as a primer at the evolutionary and ecological conception of melanoma- the framework upon which all of the information of melanoma might be hung. it truly is perfect for oncologists and melanoma researchers drawn to evolutionary idea, and evolutionary biologists and ecologists attracted to gaining insights into melanoma improvement and prevention.

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Additional info for Frontiers in Cancer Research: Evolutionary Foundations, Revolutionary Directions

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Merlo LMF, Pepper JW et al (2006) Cancer as an evolutionary and ecological process. Nat Rev Cancer 6(12):924–935 9. Greaves M, Maley CC (2012) Clonal evolution in cancer. Nature 481(7381):306–313 10. Podlaha O, Riester M et al (2012) Evolution of the cancer genome. Trends Genet 28(4):155–163 11. Horne SD, Pollick SA et al (2015) Evolutionary mechanism unifies the hallmarks of cancer. Int J Cancer 136:2012–2021 12. Aktipis CA, Maley CC, Neuberg SL (2010) Psychological barriers to evolutionary thinking in medicine.

Springer, New York, pp 1–13 79. Boerkamp K, Rutteman G et al (2012) Nuclear DNA-content in mesenchymal lesions in dogs: its value as marker of malignancy and extent of genomic instability. Cancers (Basel) 4(4):1300–1317 80. Liu YR, Kirkland B et al (2013) Development of a single-cell array for large-scale DNA fluorescence in situ hybridization. Lab Chip 13(7):1316–1324 81. Basu S, Zaidi H et al (2007) Novel quantitative techniques for assessing regional and global function and structure based on modern imaging modalities: implications for normal variation, aging and diseased states.

Bioessays 33(5):332–340 38. Shah SP, Roth A et al (2012) The clonal and mutational evolution spectrum of primary triplenegative breast cancers. Nature 486(7403):395–399 39. Shah SP, Morin RD et al (2009) Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature 461(7265):809–813 2 The Role of Theory in Cancer Research 29 40. Navin N, Kendall J et al (2011) Tumour evolution inferred by single-cell sequencing. Nature 472(7341):90–94 41. Ng CKY, Cooke SL et al (2012) The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer.

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Frontiers in Cancer Research: Evolutionary Foundations, Revolutionary Directions by Carlo C. Maley, Mel Greaves

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