Genetically Modified Plants - download pdf or read online

By Timm Wolf

ISBN-10: 1604566965

ISBN-13: 9781604566963

This booklet presents learn from world wide on Genetically transformed crops that's a plant genetically engineered to include a number of genes of one other species. the purpose is to introduce a complicated trait to the plant species which doesn't happen evidently during this species, for instance resistance to definite pests, ailments or environmental stipulations, or the creation of a undeniable nutrient or pharmaceutical agent. Genetically transformed vegetation are usually referred to as 'transgenic plants', as they comprise a number of transgenes from different organisms, in spite of the fact that, this time period additionally comprises crops within which the transgene was once built-in through obviously happening strategies.

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Some examples are the Large Scale Biology Corp. com/), Planet Biotechnology (http://www. com/). com/), and Neo Rx Corp. com/). At least 11 full size antibodies have been expressed in plants to target some of the most relevant diseases affecting human health such as cancer, HIV/AIDS or hepatitis B. Important antibodies produced in plant along with detailed information are shown in Table 1. Plantbased antibodies in comparison with those parental antibodies isolated from hybridomas are proven to show conserved biological functions suitable for efficient immunotherapy of cancer and other diseases.

This fact has worsened the situation by collaborating to a major dissemination of the infection. Therefore, an efficient and cost-effective HIV vaccine is urgently needed for its application worldwide, particularly in the less favourable regions. Plant-derived 2G12 has been produced in maize seed endosperm and studies demonstrate that it presents antigen-binding properties and neutralizing activity in vitro nearly identical to its counterpart produced in CHO cells. Although differences in the glycosylation patter have been identified, the complete functionality of this corn-derived antibody has been confirmed.

1998). This molecule is a chimeric secretory antibody (IgA/G) produced in transgenic tobacco plants by crossing of four independent transformed plants with a single transgene each of them. By this study it was demonstrated that plants have the ability to accumulate transgenes to express more complex multimeric proteins as these types of antibodies. Carox Rx was shown to have similar antigen affinity as its parental murine IgG antibody, however, its half life was three fold higher that that of its murine parent molecule due to its dimeric structure (see secretory Ig in Box 1).

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Genetically Modified Plants by Timm Wolf


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