New PDF release: Genetics and Product Formation in Streptomyces

By K. F. Chater (auth.), Simon Baumberg, Hans Krügel, Dieter Noack (eds.)

ISBN-10: 1468459228

ISBN-13: 9781468459227

ISBN-10: 1468459244

ISBN-13: 9781468459241

The Streptomycetes are industrially favourite microorganisms as a result of their skill to provide a number of various chemicals. those exhibit very assorted results upon different residing structures, and end result from profound and refined biochemical and morphological differentiation through the streptomycete lifestyles cycle. it's hence now not impressive that examine at the genetics of antibiotic biosynthesis and differentiation during this team is at the moment progressing quickly in lots of international locations. in detail attached with the creation of antibiotics is resistance to them; research of this is often giving additional information regarding the foundation and evolution of this type of genes and their hypothesized unfold between different microorganisms. one other fascinating characteristic of the Streptomyces team is their mycelial development. additionally, their ecologically vital usage of excessive molecular weight compounds calls for enzymes to be transported open air the mobilephone to hydrolyze non-diffusible substrates. ultimately, we have now as but restricted knowing of a number of the mechanisms of genome rearrangement saw in a few of these species; deletions and/or amplifications of huge quantities of DNA can ensue with no heavily affecting the viability of the organism less than laboratory stipulations. the current quantity, such as contributions addressing the above topics and others, originates from a gathering on "Genetics and Product Formation in Streptomyces" subsidized by means of the Federation of ecu Microbiological Societies in Erfurt on could 1-6 1990. in comparison to past ones of this type held in 1979, 1983 and 1987 in Weimar, you will aspect to amazing development within the research and functions of Streptomyces genetics.

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In O. Hayash1. K. ) ADP-r1bosylation React1ons. Academ1C Press, New York. :647-694. , M. Tsuchiya, Y. Imai, and M. Shimoyama. 1983. ADP-ribosylation regulates the phosphorylation of histones by the catalytic subunit of cyclic AMP-dependent protein kinase. FEBS Lett. 160:122-129. , and O. Hayaishi. 1985. ADP-ribosylation. Ann. Rev. Biochem. 54: 73-100. 27 INDUCTION OF THE STRINGENT RESPONSE IN STREPTOMYCES COELICOLOR A3(2) AND ITS POSSIBLE ROLE IN ANTIBIOTIC PRODUCTION E. Strauch, E. J. Bibb John Innes Institute, John Innes Centre for Plant Science Research, Colney Lane, Norwich, England, NR4 7UH SUMMARY The stringent response has been implicated as one of the triggers for antibiotic production and sporulation in Streptomyces (Ochi 1986; 1987b).

13. 14. 15. 16. 17. , A. Penyige, ~. Szabo, and J. C. Ensign. 1985. ADP-ribosylatlon in Streptomyces griseus. In G. Szabo, S. Biro, M. Goodfellow. ) Sixth Int. Symp. on Actlnomycetes BioI. vol. 2. Hungarlan Publishlng House. Budapest. pp. 827-829. , A. Penyige, I. Szabo, J. Barabas, and J. C. Ensign. 1988. Post-translational proteln modification by ADP-ribosylation In Streptomyces. In Y. Okaml, T. Beppu, H. Ogawara. ) BIOlogy of Actinomycetes. Japan Scientific Socleties Press. Japan. pp. 439-444.

Gen. 135:3289. M. , 1990, Cloning and characterisation of the histidine biosynthetic gene cluste of Streptomyces coelicolor A3(2), Gene, 90:31. K. , 1962, Studies on the biosynthesis of streptomycin, Appl. , 10:157. , Ebert, A. L. Hershberger, S. Queener and G. , ASM, Washington, DC. , 1985, Cloning of argG from Streptomyces Arg- mutants of S. cattleya, Bio/technology, 3:917. , 1963, Streptomycin formation by intact mycelium of Streptomyces griseus, J. , 86:1220. M. , 1989, Nucleotide sequence of a Bacillus subtilis arginine regulatory gene and homology of its product to the Escherichia coli arginine repressor, Gene, 80:29.

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Genetics and Product Formation in Streptomyces by K. F. Chater (auth.), Simon Baumberg, Hans Krügel, Dieter Noack (eds.)


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