New PDF release: Genetics: From Genes to Genomes (4th Edition)

By Michael Goldberg, Leroy Hood, Leland Hartwell, Ann Reynolds, Lee Silver

Genetics: From Genes to Genomes is a state-of-the-art, introductory genetics textual content authored through an exceptional writer group, together with Nobel Prize winner, Leland Hartwell. The 4th variation keeps to construct upon the combination of Mendelian and molecular ideas, supplying scholars with the hyperlinks among the early knowing of genetics and the recent molecular discoveries that experience replaced the best way the sphere of genetics is viewed.
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Extra info for Genetics: From Genes to Genomes (4th Edition)

Example text

For example, the two-winged fly evolved from a four-winged ancestor not because of changes in gene-encoded structural proteins, but rather because of a rewiring of the regulatory network, which converted one pair of wings into two balancing organs known as haltere (Fig. 11). Duplication of genes has allowed divergence of copies and the potential for evolution of new functions. In eukaryotes, separated exons composing a single gene allow potential rearrangements and rapid diversification. 11 Two-winged and four-winged flies.

C) Computerized analysis of chip hybridizations makes it possible to compare gene activity in any two types of cells. (a) Schematic drawing of a DNA chip A G G A C G T (Chip microarray) Segment of a chip Spot containing copies of a single DNA molecule 2. cDNA from untreated cells Cells are broken, RNA is extracted, the RNA is copied to produce complementary DNA (cDNA), and the cDNA is labeled with fluorescent tags. The cDNA represents genes that are active, that is, being converted to protein via RNA.

For simplicity, we do not show the plants that produce the peas or that grow from the planted peas. 2 Genetic Analysis According to Mendel In early 1865 at the age of 43, Gregor Mendel presented a paper entitled “Experiments on Plant Hybrids” before the Natural Science Society of Brünn. Despite its modest heading, it was a scientific paper of uncommon clarity and simplicity that summarized a decade of original observations and experiments. In it Mendel describes in detail the transmission of visible characteristics in pea plants, defines unseen but logically deduced units (genes) that determine when and how often these visible traits appear, and analyzes the behavior of genes in simple mathematical terms to reveal previously unsuspected principles of heredity.

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Genetics: From Genes to Genomes (4th Edition) by Michael Goldberg, Leroy Hood, Leland Hartwell, Ann Reynolds, Lee Silver


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