By Karsten Suhre (auth.), Karsten Suhre (eds.)
This ebook is written through best researchers within the fields concerning the intersection of genetics and metabolomics which can result in extra entire stories of inborn edition of metabolism.
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Additional resources for Genetics Meets Metabolomics: from Experiment to Systems Biology
The metabolite-world (metabolomics) reflects all functional activities, transient effects, as well as endpoints of biological processes determined by the sum of its genetic features, regulation of gene expression, protein abundance, and environmental influences. e. measuring small metabolites in a body fluid, was pioneered by Linus Pauling in 1971 . Although DNA-processing events like splicing, which result in different RNA products, can predict the number of consequently synthesized proteins [2, 3], the metabolome cannot be computed from the genome.
In the following we will describe quadrupole and ion-trap in more detail. Quadrupole For targeted metabolomics, quadrupoles are most suitable as they belong to the simplest and least expensive mass analyzers and give the most reproducible quantitative results. A quadrupole consists of four elongated and parallel ordered electrodes (rods), to which an alternating electromagnetic field is applied. Analyte ions move through the rods and reach the detector as long as they are in resonance with the frequency of the electromagnetic field.
Major Features of Technologies for Metabolomics The different approaches of metabolomics have been developed along the progress of technologies and scientific aims. e. measurements without sample fractionation or metabolite pre-separation) were performed. They were based on NMR, FT-IR spectroscopy, Raman spectroscopy, and MS [29, 46]. These types of analyses performed well, but resolution was largely enhanced when separation steps were introduced prior to metabolite identification. The separation steps may include gas chromatography (GC), multidimensional gas chromatography (GC × GC), capillary electrophoresis (CE), liquid chromatography (LC), high performance liquid chromatography (HPLC) or ultra high performance liquid chromatography (UHPLC), which all can be coupled to an analytical instrument like NMR or MS .
Genetics Meets Metabolomics: from Experiment to Systems Biology by Karsten Suhre (auth.), Karsten Suhre (eds.)