Handbook of Drug Monitoring Methods: Therapeutics and Drugs by Amitava Dasgupta PDF

By Amitava Dasgupta

ISBN-10: 1588297802

ISBN-13: 9781588297808

ISBN-10: 1597450316

ISBN-13: 9781597450317

Written in a instruction manual type with particular equipment and tips about casting off fake confident and fake unfavorable effects, this publication is a pragmatic advisor to the precise mechanisms of such occurrences.

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Additional info for Handbook of Drug Monitoring Methods: Therapeutics and Drugs of Abuse

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Ther Drug Monit 1993; 15: 375–379. 162. Salas S, Mercier C, Cicccolini J, Pourroy B, et al. Therapeutic drug monitoring for dose individualization of cisplatin in testicular cancer patients based upon total platinum measurement. Ther Drug Monit 2006; 28: 532–539. 163. Gietema JA, Meinardi MT, Messerschmidt J, Gelevert T, et al. Circulating plasma platinum more than 10 years after cisplatin treatment for testicular cancer. Lancet 2000; 355(9209): 1075–1076. 164.

Nephrotoxicity of vancomycin: alone or with an aminoglycoside. J Antimicrob Chemother 1990; 25: 679–687. 151. Cimino MA, Rotstein C, Slaughter RL, Emrich LJ. Relationship of serum antibiotic concentrations to nephrotoxicity in cancer patients receiving concurrent aminoglycoside and vancomycin therapy. Am J Med 1987; 83: 1091–1096. 152. Tan WH, Brown N, Kelsaff AW, McClure RJ, et al. Dose regimen for vancomycin not needing serum peak levels? Arch Dis Child Fetal Neonatal Ed 2002; 87: F214–216. 153.

Obtaining blood for measurement of a drug during the absorption or the distribution phase may lead to misleading information. Moreover, to measure the peak concentration of a drug, timing of the sample will depend on the route of administration. After intravenous administration, the peak concentration of a drug may be achieved in a few minutes. 9 h in one study (106). The trough concentration is clinically defined as the serum drug concentration just before the next dose. Usually, trough concentrations are monitored for most drugs, but for aminoglycosides and vancomycin, both peak and trough concentrations are monitored.

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Handbook of Drug Monitoring Methods: Therapeutics and Drugs of Abuse by Amitava Dasgupta


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