By Carole Fakhry, Gypsyamber D'Souza
This booklet serves a image of the present wisdom base in box. As human papillomavirus (HPV) reasons a emerging variety of oropharyngeal cancers, knowing the organic, medical and social implications of this an infection has turn into more and more vital for head and neck practitioners. This booklet displays the multidisciplinary nature of the clinical and medical questions taken with this illness. specialists in epidemiology, prognosis and therapy of HPV-related oropharyngeal melanoma current in-depth reports with the intention to support to enhance the reader’s knowing of this subject. The authors offer perception for solutions of universal sufferer and supplier questions on HPV an infection and similar sickness, and spotlight last inquiries to be replied within the coming years.
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2004;96:99–106. 19. Seitz HK, Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer. 2007;7:599–612. 20. Fortin A, Wang CS, Vigneault E. Influence of smoking and alcohol drinking behaviors on treatment outcomes of patients with squamous cell carcinomas of the head and neck. Int J Radiat Oncol Biol Phys. 2009;74:1062–9. 21. Browman GP, Wong G, Hodson I, et al. Influence of cigarette smoking on the efficacy of radiation therapy in head and neck cancer. N Engl J Med. 1993;328:159–63.
Higher fractions were observed in more developed regions and among men . While the overall incidence of head and neck cancer has been decreasing over the past several decades, the incidence of OPC has been increasing both in the USA and elsewhere [10–15]. The decrease for most head and neck sites is likely due to a decrease in tobacco use , whereas the increase for oropharyngeal sites corresponds to an increase in HPV in recent decades [7, 17–20], thought to be a result of changing sexual practices .
12. Talamini R, Bosetti C, La Vecchia C, et al. Combined effect of tobacco and alcohol on laryngeal cancer risk: a case–control study. Cancer Causes Control. 2002;13:957–64. 13. Giovino GA, Schooley MW, Zhu BP, et al. Surveillance for selected tobacco-use behaviors— United States, 1900–1994. MMWR CDC Surveill Summ. 1994;43:1–43. 14. Gupta AK, McKenna WG, Weber CN, et al. Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction. Clin Cancer Res. 2002;8:885–92.
HPV and Head and Neck Cancers by Carole Fakhry, Gypsyamber D'Souza