By Rolando Barbucci
This booklet is the results of a global convention amassing the main recents ends up in this box. The reviews on Biohydrogels have had a fast, exponential evolution within the final a long time. ranging from one of many first functions of hydrogels in surgical procedure, polyvinylalcohol crosslinked with formaldehyde lower than the exchange identify of Ivalon, we undergone PolyHema hydrogels as touch lens fabrics, hydrophilic polyurethanes (HPU), biodegradable hydrogels for either reconstructive surgical procedure and pharmaceutical supply structures, and eventually extra lately, one decade outdated, the thermoreversible and brief community hydrogels. after all a lot of these periods of hydrogels were continuously and consistently studied, bettering their functionality and box of purposes. lately, so much of them were used as scaffolds for cells, even stem ones, for regenerative functions (tissue engineering). however hydrogels are atypical fabrics and lots of experiences nonetheless must be conducted to totally comprehend their behaviour from mechanical, physicochemical and organic standpoint.
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Additional info for Hydrogels: Biological Properties and Applications
Borzacchiello and L. Ambrosio  Sperling LH ( 1986) Introduction to physical polymer science. Wiley, New York  De Smedt SC, Dekeyser P, Ribitsch V, Lauwers A, Demeester (1993) Viscoelastic and transient network properties of hyaluronic acid as a function of the concentration. Biorheology 30:631  Flory PJ (1953) Principles of Polymer Chemistry. Cornell University Press, New York  Schurz J (1991) Rheology of polymer solutions of the network type. Prog Polym Sci 16:1-53  Flory PJ, Rehner BD.
Barbucci 1 Hydrogels for soft tissue regeneration The degradation of Hyaluronan can be considered one of the crucial events in the loss of funcionality of several soft tissues, such as cartilage or the nucleus pulposus . Several attempts were made to counteract these degenerative processes. In particular, injection of exogeneous hyaluronan obtained from different sources, with different molecular weights and different formulation was tested . No lasting effects have ever been obtained because of the very quick degradation rate of hyaluronan which cannot be blocked without changing drastically its chemistry or activity.
Atzet Mass loss studies (not presented here) were consistent with the data in Fig. 8. Other degradation studies (not presented here) show that addition of poly( ethylene glycol) segments to the backbone chain, or addition of poly (lactic acid) segments can accelerate degradation over the rates suggested in Fig. 8. This polymer engineering permits "tuning" of degradation rates so that degradation profiles can match tissue reconstruction in tissue engineering scaffolds. Toxicology studies have been completed.
Hydrogels: Biological Properties and Applications by Rolando Barbucci