Download PDF by Leonard J. Rosenthal, Hans Wilhelm Doerr: Mechanisms of DNA tumor virus transformation

By Leonard J. Rosenthal, Hans Wilhelm Doerr

ISBN-10: 3805572476

ISBN-13: 9783805572477

Nearly 15 consistent with cent of human melanoma occurrence will be attributed to virus an infection, i.e. viruses signify the second one most crucial probability issue (after tobacco intake) for melanoma improvement in people. at the present time, 5 virus varieties are identified to be desirous about inflicting human melanoma: papillomaviruses, retroviruses, herpesviruses, hepadnaviruses, and flaviviruses. This quantity of "Monographs in Virology" offers a finished overview of a few DNA tumor viruses. major specialists within the box of tumor virology speak about up to date info, concentrating on the reworking genes of DNA tumor viruses, the mechanisms of transformation and the in vitro method used for his or her id and characterization. even supposing DNA tumor viruses are a various crew, in vitro stories have published numerous universal mechanisms of viral transformation. the person chapters of the e-book describe the newest examine at the id of viral oncogenes and their goals.

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J Neurovirol 1999;5: 430–435. Tornatore C, Berger JR, Houff SA, et al: Detection of JC virus DNA in peripheral lymphocytes from patients with and without progressive multifocal leukoencephalopathy. Ann Neurol 1992; 31:454 – 462. Yogo Y, Kitamura T, Sugimoto C, et al: Isolation of a possible archetypal JC virus DNA sequence from nonimmunocompromised individuals. J Virol 1990;64:3139–3143. Negrini M, Sabbioni S, Arthur RR, Castagnoli A, Barbanti-Brodano G: Prevalence of the archetypal regulatory region and sequence polymorphisms in nonpassaged BK virus variants.

DNA extracted from the insulinoma was transfected into human embryonic fibroblasts with subsequent rescue of an isolate now called BKV-IR. BKV-IR was able to transform hamster kidney cells in vitro and had a deletion and insertion in the regulatory region setting it apart from wild-type BKV. This particular study was important in that BKV was known to produce pancreatic tumors in hamsters and now had a correlate in man. In a later study, Negrini et al. [98] also found episomal BKV DNA in Kaposi’s sarcoma, Ewing and osteogenic sarcoma, glioma, meningioma and neuroblastoma.

Since the E143R mutant retains the ability to associate with wild-type 16K [40], this interaction may inhibit the activity of the pump. These genetic and biochemical findings indicate a potential role for 16K in E5 transformation. Conclusions The results described above provide strong evidence that the BPV-1 E5 oncoprotein transforms fibroblasts through specific activation of a growth factor receptor, the ␤-type PDGF-R. The mechanism by which the viral protein elicits BPV-1 E5 Oncoprotein 39 transforming ability through this PTK receptor represents a divergence from previously described mechanisms involving growth factors and their respective receptors.

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Mechanisms of DNA tumor virus transformation by Leonard J. Rosenthal, Hans Wilhelm Doerr


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