By Guido Bocci, Giulio Francia
This booklet analyzes all points of metronomic chemotherapy, a brand new technique concerning low-dose, long term, and often administered treatment that has preclinical and medical job in numerous tumors. After a gap part at the pharmacological bases of metronomic chemotherapy, together with its antiangiogenic results and influence on immunity, preclinical stories on a number of sessions of drug are mentioned. medical functions of metronomic chemotherapy in a large choice of tumors are then addressed intimately, with description of the result of all released reports. The scientific pharmacology of metronomic chemotherapy is additionally thought of extensive, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and opposed drug reactions. The booklet closes by means of describing the function of this treatment within the veterinarian clinic.
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Additional resources for Metronomic Chemotherapy: Pharmacology and Clinical Applications
Ann Oncol 24:2310–2316 79. Perroud HA, Rico MJ, Alasino CM, Queralt F, Mainetti LE, Pezzotto SM, Rozados VR, Scharovsky OG (2013) Safety and therapeutic effect of metronomic chemotherapy with cyclophosphamide and celecoxib in advanced breast cancer patients. Future Oncol 9:451–462 80. Mainetti LE, Rozados VR, Rossa A, Bonfil RD, Scharovsky OG (2011) Antitumoral and antimetastatic effects of metronomic chemotherapy with cyclophosphamide combined with celecoxib on murine mammary adenocarcinomas. J Cancer Res Clin Oncol 137:151–163 81.
Ongoing research into new treatment modalities which can kill CSCs are currently being undertaken . In terms of angiogenesis, a growing body of evidence suggests that CSCs require angiogenic factors and blood vessels to maintain their characteristics. CSCs were found to reside in close proximity to tumor vasculature [64, 65]. Disrupting the VEGF-neuropilin axis was found to decrease the number of CSCs, suggesting that CSCs are angiogenic or VEGF dependent [65, 66]. CSCs of C6 rat gliomas secrete both VEGF and SDF-1 used to promote systemic and local angiogenesis thereby contributing to tumor growth .
Clin Cancer Res 8:221–232 12. Hahnfeldt P, Hlatky L, Klement GL (2013) Center of cancer systems biology second annual workshop–tumor metronomics: timing and dose level dynamics. Cancer Res 73:2949–2954 13. Mayer EL, Isakoff SJ, Klement G, Downing SR, Chen WY, Hannagan K, Gelman R, Winer EP, Burstein HJ (2012) Combination antiangiogenic therapy in advanced breast cancer: a phase 1 trial of vandetanib, a VEGFR inhibitor, and metronomic chemotherapy, with correlative platelet proteomics. Breast Cancer Res Treat 136:169–178 14.
Metronomic Chemotherapy: Pharmacology and Clinical Applications by Guido Bocci, Giulio Francia