Download e-book for iPad: Nanotechnology-Based Precision Tools for the Detection and by Chad A. Mirkin, Thomas J. Meade, Sarah Hurst Petrosko,

By Chad A. Mirkin, Thomas J. Meade, Sarah Hurst Petrosko, Alexander H. Stegh

ISBN-10: 2272452752

ISBN-13: 9782272452756

ISBN-10: 3319165542

ISBN-13: 9783319165547

ISBN-10: 3319165550

ISBN-13: 9783319165554

This e-book discusses rising nanotechnology-based instruments that experience the aptitude to dramatically impression melanoma study, diagnostics, and therapy. melanoma is a fancy, devastating, and debilitating illness and, even though a lot development has been made, novel, more advantageous diagnostic and treatments are nonetheless wanted, in particular for complex cancers. the final word objective is to become aware of melanoma early and non-invasively and to supply efficacious and designated precision remedies that reason fewer damaging negative effects. This publication explains how nanotechnology can make the most the size-, shape-, and composition-dependent homes of nanomaterials to supply novel instruments for precision melanoma drugs. will probably be of curiosity to researchers and pros operating within the fields of chemistry, biology, fabrics technology and engineering, and medication who are looking to study extra approximately this attention-grabbing and fast moving sector of research.

Show description

Read Online or Download Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer PDF

Best forensic medicine books

Download e-book for iPad: Essential Forensic Pathology: Core Studies and Exercises by Gilbert Corrigan

A myriad of alternative eventualities wait for these coming into the sphere of forensic pathology, starting from gunshot wounds to asphyxiation to explosives to dying from habit. crucial Forensic Pathology: middle reports and workouts is helping arrange pathologists in education via constructing what they have to find out about the commonest dying scenes they are going to stumble upon.

Ronald Roesch's Psychology and Law: The State of the Discipline PDF

As legislations is instituted by means of society to serve society, there will be absolute confidence that psychology performs an enormous and inevitable function within the criminal technique, clarifying or complicating felony concerns. during this enlightening textual content, Roesch, Hart, Ogloff, and the individuals evaluate the entire key parts of using mental services in civil, legal, and relatives legislations.

Unimagined Community: Sex, Networks, and AIDS in Uganda and - download pdf or read online

This groundbreaking paintings, with its specific anthropological technique, sheds new mild on a principal conundrum surrounding AIDS in Africa. Robert J. Thornton explores why HIV incidence fell through the Nineties in Uganda regardless of that country's having considered one of Africa's maximum fertility charges, whereas through the related interval HIV incidence rose in South Africa, the rustic with Africa's lowest fertility cost.

Additional info for Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer

Sample text

The former method involves sequence-specific binding of ASOs to target mRNA in the cytoplasm, thereby preventing ribosomal translation of the mRNA (Fig. 1a). The latter mechanism involves RNase H-dependent cleavage, in which RNase H recognizes an RNA– DNA heteroduplex, selectively cleaves the RNA strand, and releases the intact DNA strand [10]. The intact DNA strand can then engage additional target mRNAs and recruit RNase H, enhancing its potency. 2 The RNA Interference (RNAi) Pathway Fire and Mello first reported the discovery of RNAi-based gene silencing in Caenorhabditis elegans in 1998.

Hence, these SNA-antibody constructs are capable of increasing both the selectivity and efficacy of the SNA platform. 3 Gadolinium-Enriched SNAs for Cellular Imaging The Meade and Mirkin labs utilized SNAs as a platform to synthesize bioactivated contrast agents that are capable of penetrating cells for use in cell-tracking experiments [100]. The most commonly used contrast agents, paramagnetic gadolinium (III) (GdIII) complexes, are advantageous because GdIII complexes have high relaxivities since they reduce the longitudinal relaxation time (T1) of local water protons [101].

6b), and specifically colocalized with microtubules Fig. 6 Drug and oligonucleotide dual therapy. a Scheme for the synthesis of Pt (IV) terminated SNAs; b Live cell imaging of HeLa cells upon incubation with platinum-tethered Cy5-SNAs for 12 h; c Co-localization of the particles with the cytoplasmic microtubules. Hoechst 33342 was used for nuclear staining. Scale bars, 20 μm. Adapted with permission from Dhar et al. [89]. Copyright 2009. American Chemical Society Therapeutic Applications of Spherical Nucleic Acids 37 (Fig.

Download PDF sample

Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer by Chad A. Mirkin, Thomas J. Meade, Sarah Hurst Petrosko, Alexander H. Stegh

by Anthony

Rated 4.53 of 5 – based on 11 votes