By Chad A. Mirkin, Thomas J. Meade, Sarah Hurst Petrosko, Alexander H. Stegh
This e-book discusses rising nanotechnology-based instruments that experience the aptitude to dramatically impression melanoma study, diagnostics, and therapy. melanoma is a fancy, devastating, and debilitating illness and, even though a lot development has been made, novel, more advantageous diagnostic and treatments are nonetheless wanted, in particular for complex cancers. the final word objective is to become aware of melanoma early and non-invasively and to supply efficacious and designated precision remedies that reason fewer damaging negative effects. This publication explains how nanotechnology can make the most the size-, shape-, and composition-dependent homes of nanomaterials to supply novel instruments for precision melanoma drugs. will probably be of curiosity to researchers and pros operating within the fields of chemistry, biology, fabrics technology and engineering, and medication who are looking to study extra approximately this attention-grabbing and fast moving sector of research.
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Additional info for Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer
The former method involves sequence-speciﬁc binding of ASOs to target mRNA in the cytoplasm, thereby preventing ribosomal translation of the mRNA (Fig. 1a). The latter mechanism involves RNase H-dependent cleavage, in which RNase H recognizes an RNA– DNA heteroduplex, selectively cleaves the RNA strand, and releases the intact DNA strand . The intact DNA strand can then engage additional target mRNAs and recruit RNase H, enhancing its potency. 2 The RNA Interference (RNAi) Pathway Fire and Mello ﬁrst reported the discovery of RNAi-based gene silencing in Caenorhabditis elegans in 1998.
Hence, these SNA-antibody constructs are capable of increasing both the selectivity and efﬁcacy of the SNA platform. 3 Gadolinium-Enriched SNAs for Cellular Imaging The Meade and Mirkin labs utilized SNAs as a platform to synthesize bioactivated contrast agents that are capable of penetrating cells for use in cell-tracking experiments . The most commonly used contrast agents, paramagnetic gadolinium (III) (GdIII) complexes, are advantageous because GdIII complexes have high relaxivities since they reduce the longitudinal relaxation time (T1) of local water protons .
6b), and speciﬁcally colocalized with microtubules Fig. 6 Drug and oligonucleotide dual therapy. a Scheme for the synthesis of Pt (IV) terminated SNAs; b Live cell imaging of HeLa cells upon incubation with platinum-tethered Cy5-SNAs for 12 h; c Co-localization of the particles with the cytoplasmic microtubules. Hoechst 33342 was used for nuclear staining. Scale bars, 20 μm. Adapted with permission from Dhar et al. . Copyright 2009. American Chemical Society Therapeutic Applications of Spherical Nucleic Acids 37 (Fig.
Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer by Chad A. Mirkin, Thomas J. Meade, Sarah Hurst Petrosko, Alexander H. Stegh