By Anshu Mathur
Nanotechnology in Cancer covers present nanotechnology-based nanotherapeutics concerning gold nanoparticles, colloids, gels, magnetic nanoparticles, radiofrequency, gene remedy, organic debris, and the intermolecular interactions linked to nanoparticle dependent melanoma treatment in vivo.
Different melanoma kinds and destinations are thought of along the corresponding remedy forms, and using imaging applied sciences and animal types also are explored. either clinical and medical points are thought of by means of authors coming from either fields, with the authors utilizing their backgrounds from assorted disciplines to make the relationship among melanoma and powerful drug supply and healing strategies.
- Authored through leaders from the medical study and medical groups who use their heritage from assorted disciplines to discover the connections among melanoma and powerful drug supply and healing strategies
- Brings jointly tumor biology, imaging applied sciences, nanomaterial structures for drug supply, healing thoughts, and reconstructive surgery
- Explores the scientific and regulatory demanding situations dealing with nanomedicine
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Extra info for Nanotechnology in Cancer
Relative protein levels were determined by interpolation from each dilution curve obtained from the standard curve of the slide. Data was normalized for protein loading and transformed into log2 values, which were used for identifying expression patterns. com; Ingenuity Systems, Redwood City, CA, USA). 1 Complete List of Genes Representing the Proteins Investigated Using the Protein Array ACACA ACACB ACVRL1 AKT1 AKT1S1 AKT2 AKT3 ANXA1 ANXA7 AR BAD BAX BCL2 BCL2L1 BCL2L11 BECN1 BID BIRC2 BRAF C12orf5 CASP7 CASP8 CAV1 CCNB1 CCND1 CCNE1 CDC2 CDH1 CDH2 CDKN1B CHEK1 CHEK2 CLDN7 COL6A1 CTNNA1 CTNNB1 DIABLO DVL3 EEF2 EEF2K EGFR EIF4E EIF4EBP1 EIF4G1 ERBB2 ERBB3 ERCC1 ERRFI1 ESR1 FASN FN1 FOXM1 FOXO3 FRAP1 G6PD GAB2 GAPDH GATA3 GSK3A GSK3B IGFBP2 INPP4B IRS1 ITGA2 KDR KIT KRAS LCK MAP2K1 MAPK1 MAPK8 MAPK9 MAPK14 MET MGMT MSH2 MSH6 MYC MYH11 NDRG NF2 NFkB1 NOTCH1 NRAS PARK7 PARP1 PCNA PDCD4 PDK1 PEA15 PECAM1 PGR PIK3CA PIK3R1 PRKAA1 PRKCA PRKCB PRKCD PTEN PXN RAB11A RAB25 RAD50 RAD51 RAF1 RB1 RBM15 RICTOR RPS6 RPS6KA1 RPS6KB1 RPTOR SCD SETD2 SFRS1 SMAD1 SMAD3 SMAD4 SNAI2 SRC STAT3 STAT5A STMN1 SYK TFRC TGM2 TP53 TP53BP1 VHL WWTR1 XRCC1 YAP1 YBX1 YWHAB YWHAE YWHAZ silk nanoparticles for curcumin-loaded nanoparticles to remove the effects of the vehicle.
Free curcumin treatment caused the upregulation of β-catenin and GSK3B, although it did not change the expression levels of c-Myc and cyclin-D1. Therefore the upregulation of GSK3B prevented the transport of β-catenin from the cytoplasm to the nucleus, thereby preventing cell proliferation (Fig. 15). Based on the IPA analysis, protein expression for the cell group treated with 50 μM curcumin-loaded nanoparticles for 48 hours was correlated with existing canonical pathways, and a list of more than 200 potential pathways were reported sorted by the highest concurrence rate, of which the top 5 pathways are listed in Fig.
REFERENCES  Roussakow S. The history of hyperthermia rise and decline. Conf Papers Med 2013;2013:40.  Abe M, Hiraoka M, Takahashi M, Egawa S, Matsuda C, Onoyama Y, et al. Multiinstitutional studies on hyperthermia using an 8-MHz radiofrequency capacitive heating device (thermotron RF-8) in combination with radiation for cancer therapy. Cancer 1986;58:1589À95.  Issels RD, Lindner LH, Verweij J, Wust P, Reichardt P, Schem B-C, et al. Neoadjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study.
Nanotechnology in Cancer by Anshu Mathur