By V. Sayakanit, Virulh Sa-Yakanit, Leif Matsson, Hans Frauenfelder
Like inanimate subject, organic subject is condensed, notwithstanding it can be extra complicated. although, a dwelling mobilephone is a chemically open process with organic services which are frequently a non-stationary, non-linear form of collective phenomena pushed by way of chemical reactants, for instance ATP, GTP, ligands and receptors. The residing telephone and lots of of its subsystems are accordingly lyotropic structures, looking on quite a few reactant concentrations instead of the temperature. Non-local and native correlations of the interacting molecules turn into the necessities for sign transduction. This ebook constitutes the lawsuits of the workshop entitled "Biological Physics 2000".
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Extra info for Proceedings of the first Workshop on Biological Physics 2000: Chulalongkorn University, Bangkok, Thailand, September 18-22, 2000
A receptor is a protein, or a complex structure consisting of proteins and other biopolymers, which somehow binds specifically with a certain ligand. Usually the receptors are embedded in the outer membrane of the cell. , a ligand-receptor complex is formed almost immediately. This process of a highly selective interaction of the cell with specific ligands in its environment is called chemoreception. The biological and biochemical aspects of chemoreception are fairly well understood, and the physical principles involved have been explored by a small number of physicists and biophysicists.
5) The average distance d between the N representative points in shape space is given by R nNTinlZ) if the biologically relevant part of shape space is modelled by an n-dimensional sphere of radius R. The gamma-function is denoted by T . If instead the relevant part of shape space were modelled by a cube with side R, then the last equation should be replaced by d —= N R -ii „ . 7) It is instructive to illustrate these results with a numerical example, which holds for humans and mice equally. The first-passage time Ta will, of course, again be identified with TR, the time typical for immune maturations; say Ta = 2 weeks.
Structural fluctuations are necessary to make possible the reversible binding of oxygen . In several proteins with enzymatic activity two conformations exist, one with a substrate bound to the catalytic center and one where this center is unoccupied. Such different conformations can be well characterized by X-ray structure analysis. However, not much is known how the molecule changes from one conformation to the other. But it is obvious that, for a conformational change, the molecule needs some flexibility.
Proceedings of the first Workshop on Biological Physics 2000: Chulalongkorn University, Bangkok, Thailand, September 18-22, 2000 by V. Sayakanit, Virulh Sa-Yakanit, Leif Matsson, Hans Frauenfelder